Promethazine suppositories are for rectal use only. Do not endeavor to swallow the suppositories or insert in some other Element of Your system.
This medication has been prescribed to your current ailment only. Usually do not use it afterwards for one more situation Until informed to do so by your doctor. Another medication may very well be vital in People instances.
The consequences of concomitant use or discontinuation of cytochrome P450 3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors with codeine are complex, requiring careful consideration of the effects on the parent drug, codeine, as well as the Energetic metabolite, morphine.
In deciding to employ a drugs, the risks of getting the medicine need to be weighed towards the good it'll do. This really is a call you and your health care provider can make. For this drugs, the following need to be regarded as:
If you do not Possess a drug just take-again place in your area, flush any unused narcotic medicine down the toilet. Test your local drug retail outlet and clinics for get-back again places. You may as well Examine the DEA Site for destinations. Here is the website link on the FDA Secure disposal of medicines website:
Employing this drugs with any of the following might trigger a heightened risk of certain Unintended effects but could possibly be unavoidable occasionally. If applied alongside one another, your health practitioner may possibly change the dose or how often you use this drugs, or Provide you with Exclusive Guidelines about the use of meals, Liquor, or tobacco.
Thoroughly measure the dose using a special measuring gadget/spoon. Will not make use of a house spoon since you may well not get the right dose.
The concomitant usage of Promethazine with Codeine Oral Answer with all cytochrome P450 3A4 inducers or discontinuation of a cytochrome P450 3A4 inhibitor may perhaps cause decrease codeine concentrations, better norcodeine degrees, and less metabolism by way of 2D6 with resultant lessen morphine concentrations. This can be linked to a minimize in efficacy, and in a few clients, could result Promethazine codeine syrup in signals and indications of opioid withdrawal.
The next really serious adverse reactions are described, or described in greater detail, in other sections:
If this SPL consists of inactivated NDCs shown because of the FDA initiated compliance motion, They are going to be specified as such.
These symptoms may indicate you are an "extremely-immediate metabolizer of codeine". Due to this fact, there is far too much morphine in your body and much more Unwanted effects of morphine than typical. Little ones may be In particular delicate to this impact. Usually do not give this medication to:
Doctors prescribe codeine for gentle to average acute and Long-term soreness, frequently during most cancers treatment method or as A part of supportive care for individuals with serious well being disorders.
The moment the triage nurse has admitted a codeine overdose, the crisis department clinician is to blame for coordinating the treatment, which can incorporate any number of the next:
The following major adverse reactions are explained, or explained in larger element, in other sections: